abstract：BACKGROUND:The Exercise Intensity Trial (EXcITe) is a randomized trial to compare the efficacy of supervised moderate-intensity aerobic training to moderate to high-intensity aerobic training, relative to attention control, on aerobic capacity, physiologic mechanisms, patient-reported outcomes, and biomarkers in women ...

journal_title：BMC cancer

authors： Jones LW,Douglas PS,Eves ND,Marcom PK,Kraus WE,Herndon JE 2nd,Inman BA,Allen JD,Peppercorn J

更新日期：2010-10-06 00:00:00

abstract：BACKGROUND:As a key gene in the immunosurveillance of cell malignancy, Cytotoxic T-lymphocyte antigen 4 (CTLA-4 is an important negative regulator of T cell activation and proliferation. The CTLA-4 +49G > A polymorphism is one of the most commonly studied polymorphisms in this gene due to its association with cancer ri...

journal_title：BMC cancer

authors： Zheng J,Yu X,Jiang L,Xiao M,Bai B,Lu J,Zhou Y

更新日期：2010-10-04 00:00:00

abstract：BACKGROUND:The enhancer of zeste homolog 2 (EZH2) gene exerts oncogene-like activities and its (over)expression has been linked to several human malignancies. Here, we studied a possible association between EZH2 expression and prognosis in patients with renal cell carcinoma (RCC). METHODS:EZH2 protein expression in RC...

journal_title：BMC cancer

authors： Wagener N,Macher-Goeppinger S,Pritsch M,Hüsing J,Hoppe-Seyler K,Schirmacher P,Pfitzenmaier J,Haferkamp A,Hoppe-Seyler F,Hohenfellner M

更新日期：2010-10-04 00:00:00

abstract：BACKGROUND:Association between rectal or colon cancer risk and serine hydroxymethyltransferase 1 (SHMT1) C1420T or methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms was assessed. The serum total homocysteine (HCY), marker of folate metabolism was also investigated. METHODS:The SHMT1 and MTHFR genotypes w...

journal_title：BMC cancer

authors： Komlósi V,Hitre E,Pap E,Adleff V,Réti A,Székely E,Bíró A,Rudnai P,Schoket B,Müller J,Tóth B,Ottó S,Kásler M,Kralovánszky J,Budai B

更新日期：2010-10-04 00:00:00

abstract：BACKGROUND:An understanding of growth dynamics of tumors is important in understanding progression of cancer and designing appropriate treatment strategies. We perform a comparative study of the hyperbolastic growth models with the Weibull and Gompertz models, which are prevalently used in the field of tumor growth. M...

journal_title：BMC cancer

authors： Eby WM,Tabatabai MA,Bursac Z

更新日期：2010-09-23 00:00:00

abstract：BACKGROUND:Increased mammographic breast density is a moderate risk factor for breast cancer. Different scales have been proposed for classifying mammographic density. This study sought to assess intra-rater agreement for the most widely used scales (Wolfe, Tabár, BI-RADS and Boyd) and compare them in terms of classify...

journal_title：BMC cancer

authors： Garrido-Estepa M,Ruiz-Perales F,Miranda J,Ascunce N,González-Román I,Sánchez-Contador C,Santamariña C,Moreo P,Vidal C,Peris M,Moreno MP,Váquez-Carrete JA,Collado-García F,Casanova F,Ederra M,Salas D,Pollán M,DDM-Spain.

更新日期：2010-09-13 00:00:00

abstract：BACKGROUND:Treatment standard for patients with primary glioblastoma (GBM) is combined radiochemotherapy with temozolomide (TMZ). Radiation is delivered up to a total dose of 60 Gy using photons. Using this treatment regimen, overall survival could be extended significantly however, median overall survival is still onl...

journal_title：BMC cancer

authors： Combs SE,Kieser M,Rieken S,Habermehl D,Jäkel O,Haberer T,Nikoghosyan A,Haselmann R,Unterberg A,Wick W,Debus J

更新日期：2010-09-06 00:00:00

abstract：BACKGROUND:BRCA1 and BRCA2 mutations are found in a proportion of families with multiple early-onset breast cancers. There are a large number of different deleterious mutations in both genes, none of which would be detectable using standard genetic association studies. Single common variants and haplotypes of common va...

journal_title：BMC cancer

authors： Turkovic L,Gurrin LC,Bahlo M,Dite GS,Southey MC,Hopper JL

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Severe toxicity to 5-fluorouracil (5-FU) based chemotherapy in gastrointestinal cancer has been associated with constitutional genetic alterations of the dihydropyrimidine dehydrogenase gene (DPYD). METHODS:In this study, we evaluated DPYD promoter methylation through quantitative methylation-specific PCR a...

journal_title：BMC cancer

authors： Savva-Bordalo J,Ramalho-Carvalho J,Pinheiro M,Costa VL,Rodrigues A,Dias PC,Veiga I,Machado M,Teixeira MR,Henrique R,Jerónimo C

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature cells that accumulates in tumour-bearing hosts. These cells are induced by tumour-derived factors (e.g. prostaglandins) and have a critical role in immune suppression. MDSC suppress T and NK cell function via increased express...

journal_title：BMC cancer

authors： Veltman JD,Lambers ME,van Nimwegen M,Hendriks RW,Hoogsteden HC,Aerts JG,Hegmans JP

更新日期：2010-08-30 00:00:00

abstract：BACKGROUND:Breast cancer is the most common form of malignancy affecting women worldwide. It is also the leading cancer in females in Cyprus, with approximately 400 new cases diagnosed annually. It is well recognized that genetic variation as well as environmental factors modulate breast cancer risk. The main aim of th...

journal_title：BMC cancer

authors： Hadjisavvas A,Loizidou MA,Middleton N,Michael T,Papachristoforou R,Kakouri E,Daniel M,Papadopoulos P,Malas S,Marcou Y,Kyriacou K

更新日期：2010-08-23 00:00:00

abstract：BACKGROUND:Based on their different mechanisms of action, non-overlapping side effects and radiosensitising potential, combining the antimetabolites pemetrexed (multitargeted antifolate, MTA) and gemcitabine (2',2'-difluorodeoxycytidine, dFdC) with irradiation (RT) seems promising. This in vitro study, for the first ti...

journal_title：BMC cancer

authors： Wouters A,Pauwels B,Lardon F,Pattyn GG,Lambrechts HA,Baay M,Meijnders P,Vermorken JB

更新日期：2010-08-19 00:00:00

abstract：BACKGROUND:Heterogeneous nuclear ribonucleoproteins (hnRNPs) of the A/B type (hnRNP A1, A2/B1, A3) are highly related multifunctional proteins participating in alternative splicing by antagonising other splicing factors, notably ASF/SF2. The altered expression pattern of hnRNP A2/B1 and/or splicing variant B1 alone in ...

journal_title：BMC cancer

authors： Boukakis G,Patrinou-Georgoula M,Lekarakou M,Valavanis C,Guialis A

更新日期：2010-08-17 00:00:00

abstract：BACKGROUND:Cervical dysplasia and tumorigenesis have been linked with numerous chromosomal aberrations. The goal of this study was to evaluate 35 genomic regions associated with cervical disease and to select those which were found to have the highest frequency of aberration for use as probes in fluorescent in-situ hyb...

journal_title：BMC cancer

authors： Policht FA,Song M,Sitailo S,O'Hare A,Ashfaq R,Muller CY,Morrison LE,King W,Sokolova IA

更新日期：2010-08-16 00:00:00

abstract：BACKGROUND:H. pylori, whose infection increases tumor invasiveness and metastasis, is generally labelled as the strongest risk factor for the development of gastric cancer. It appears not to be a coincidence that there is also an overexpression of CXCR4 and an obvious involvement in gastric cancer metastasis. The aim o...

journal_title：BMC cancer

authors： Zhao C,Lu X,Bu X,Zhang N,Wang W

更新日期：2010-08-11 00:00:00

abstract：BACKGROUND:Extramammary Paget's disease (EMPD) remains a rare condition with only a limited number of cases reported in the literature. EMPD is mainly composed of intraepidermal Paget cells, and possesses variable clinical behaviors and histological appearances, leading to difficulty in the diagnosis of this disease. ...

journal_title：BMC cancer

authors： Wang X,Yang W,Yang J

更新日期：2010-08-04 00:00:00

abstract：BACKGROUND:Colorectal peritoneal carcinomatosis (CRPC) is a common form of systemic metastasis of intra-abdominal cancers. Intraperitoneal chemotherapy is a preferable option for colorectal cancer. Here we reported that a new system, 5-FU-loaded hydrogel system, can improve the therapeutic effects of intraperitoneal ch...

journal_title：BMC cancer

authors： Wang Y,Gong C,Yang L,Wu Q,Shi S,Shi H,Qian Z,Wei Y

更新日期：2010-08-02 00:00:00

abstract：BACKGROUND:To help design clinical trials of adjuvant bisphosphonate therapy for breast cancer, the temporal incidence of bone metastasis was investigated in a cohort of patients. We have tried to draw the criteria to use adjuvant bisphosphonate. METHODS:Consecutive breast cancer patients undergoing surgery between 19...

journal_title：BMC cancer

authors： Koizumi M,Yoshimoto M,Kasumi F,Iwase T

更新日期：2010-07-21 00:00:00

abstract：INTRODUCTION:Metastasis represents a major adverse step in the progression of breast carcinoma. Lymph node invasion is the most relevant prognostic factor; however little is known on the molecular events associated with lymph node metastasis process. This study is to investigate the status and role of methylation in ly...

journal_title：BMC cancer

authors： Feng W,Orlandi R,Zhao N,Carcangiu ML,Tagliabue E,Xu J,Bast RC Jr,Yu Y

更新日期：2010-07-20 00:00:00

abstract：BACKGROUND:Risk estimation of gastrointestinal stromal tumours (GIST) is based on tumour size and mitotic rate according to the National Institutes of Health consensus classification. The indication for adjuvant treatment of patients with high risk GIST after R0 resection with small molecule inhibitors is still a contr...

journal_title：BMC cancer

authors： Dorn J,Spatz H,Schmieder M,Barth TF,Blatz A,Henne-Bruns D,Knippschild U,Kramer K

更新日期：2010-07-02 00:00:00

abstract：BACKGROUND:The oncofetal protein insulin-like growth factor II mRNA binding protein 3 (IMP3) is an important factor for cell-migration and adhesion in malignancies. Recent studies have shown a remarkable overexpression of IMP3 in different human malignant neoplasms and also revealed it as an important prognostic marker...

journal_title：BMC cancer

authors： Ikenberg K,Fritzsche FR,Zuerrer-Haerdi U,Hofmann I,Hermanns T,Seifert H,Müntener M,Provenzano M,Sulser T,Behnke S,Gerhardt J,Mortezavi A,Wild P,Hofstädter F,Burger M,Moch H,Kristiansen G

更新日期：2010-06-30 00:00:00

abstract：BACKGROUND:Pemphigus vulgaris (PV) is an autoimmune blistering disease of the skin and mucous membranes. Genital involvement occurs when most other common sites are concurrently affected or are in remission. Systemic lupus erythematosus (SLE) is an autoimmune disease that may affect many parts of the body and the skin ...

journal_title：BMC cancer

authors： Bifulco G,Mandato VD,Piccoli R,Giampaolino P,Mignogna C,Mignogna MD,Costagliola L,Nappi C

更新日期：2010-06-23 00:00:00

abstract：BACKGROUND:Genome wide association studies (GWAS) have identified several genetic variants that are associated with prostate cancer. Most of these variants, like other GWAS association signals, are located in non-coding regions of potential candidate genes, and thus could act at the level of the mRNA transcript. METHO...

journal_title：BMC cancer

authors： Harries LW,Perry JR,McCullagh P,Crundwell M

更新日期：2010-06-22 00:00:00

abstract：BACKGROUND:The cytochrome P450 (CYP) enzymes 2C19, 2D6, and 3A5 are responsible for converting the selective estrogen receptor modulator (SERM), tamoxifen to its active metabolites 4-hydroxy-tamoxifen (4OHtam) and 4-hydroxy-N-demethyltamoxifen (4OHNDtam, endoxifen). Inter-individual variations of the activity of these ...

journal_title：BMC cancer

authors： Gjerde J,Geisler J,Lundgren S,Ekse D,Varhaug JE,Mellgren G,Steen VM,Lien EA

更新日期：2010-06-21 00:00:00

abstract：BACKGROUND:Eradication of early gastric carcinoma (GC) is thought to contribute to reduction in the mortality of GC, given that most of the early GCs progress to the advanced GCs. However, early GC is alternatively considered a dormant variant of GC, and it infrequently progresses to advanced GC. The aim of this study ...

journal_title：BMC cancer

authors： Nakayama T,Ling ZQ,Mukaisho K,Hattori T,Sugihara H

更新日期：2010-06-21 00:00:00

abstract：BACKGROUND:We conducted a retrospective study in our hospital in which we compared D1 with D3 through D2 lymphadenectomy for gastric cancer in terms of morbidity, postoperative mortality, long-term survival after surgery. METHODS:567 patients who were performed curative intent between 1980 and 2003 were enrolled. 187 ...

journal_title：BMC cancer

authors： Zhang H,Liu C,Wu D,Meng Y,Song R,Lu P,Wang S

更新日期：2010-06-20 00:00:00

abstract：BACKGROUND:We conducted a case-control study in the greater Toronto area to evaluate potential lung cancer risk factors including environmental tobacco smoke (ETS) exposure, family history of cancer, indoor air pollution, workplace exposures and history of previous respiratory diseases with special consideration given ...

journal_title：BMC cancer

authors： Brenner DR,Hung RJ,Tsao MS,Shepherd FA,Johnston MR,Narod S,Rubenstein W,McLaughlin JR

更新日期：2010-06-14 00:00:00

abstract：BACKGROUND:Isothiocyanates are natural compounds found in consumable cruciferous vegetables. They have been shown to inhibit chemical carcinogenesis by a wide variety of chemical carcinogens in animal models. Recent studies have also shown that isothiocyanates have antitumor activity, inhibiting the growth of several t...

journal_title：BMC cancer

authors： Wu X,Zhu Y,Yan H,Liu B,Li Y,Zhou Q,Xu K

更新日期：2010-06-09 00:00:00

abstract：BACKGROUND:Ethyl carbamate (EC) is a multi-site carcinogen in experimental animals and probably carcinogenic to humans (IARC group 2A). Traces of EC below health-relevant ranges naturally occur in several fermented foods and beverages, while higher concentrations above 1 mg/l are regularly detected in only certain spir...

journal_title：BMC cancer

authors： Lachenmeier DW,Lima MC,Nóbrega IC,Pereira JA,Kerr-Corrêa F,Kanteres F,Rehm J

更新日期：2010-06-08 00:00:00

abstract：BACKGROUND:The immune system plays an important role in the multifactorial biologic system during the development of neoplasias. However, the involvement of the inflammatory response in the promotion/control of malignant cells is still controversial, and the cell subsets and the mechanisms involved are poorly investiga...

journal_title：BMC cancer

authors： Estrela-Lima A,Araújo MS,Costa-Neto JM,Teixeira-Carvalho A,Barrouin-Melo SM,Cardoso SV,Martins-Filho OA,Serakides R,Cassali GD

更新日期：2010-06-04 00:00:00

abstract：BACKGROUND:Cervical cancer represents an important global public health problem. It is the 2nd most common cancer among women worldwide. Human papillomavirus (HPV) infection is now well-established as a necessary cause of invasive cervical cancer (ICC) development. Only a few studies on HPV prevalence and type-specific...

journal_title：BMC cancer

authors： Mariani L,Monfulleda N,Alemany L,Vizza E,Marandino F,Vocaturo A,Benevolo M,Quirós B,Lloveras B,Klaustermeier JE,Quint W,de Sanjosé S,Bosch FX

更新日期：2010-06-04 00:00:00

abstract：BACKGROUND:The serine/threonine kinase PIM1 has been implicated as an oncogene in various human cancers including lymphomas, gastric, colorectal and prostate carcinomas. In mouse models, Pim1 is known to cooperate with c-Myc to promote tumorigenicity. However, there has been limited analysis of the tumorigenic potentia...

journal_title：BMC cancer

authors： Kim J,Roh M,Abdulkadir SA

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Obesity is a global phenomenon and is associated with various types of cancer, including colon cancer. There is a growing interest for safe and effective bioactive compounds that suppress the risk for obesity-promoted colon cancer. Resveratrol (trans-3, 4', 5,-trihydroxystilbene), a stilbenoid found in the s...

journal_title：BMC cancer

authors： Vanamala J,Reddivari L,Radhakrishnan S,Tarver C

更新日期：2010-05-26 00:00:00

abstract：BACKGROUND:We evaluated if the survival benefit of adding rituximab to standard chemotherapy for non-Hodgkin lymphoma (NHL) observed in clinical trials has been experienced by an Australian NHL patient population. METHODS:NHL cases diagnosed in 1985-2004 in New South Wales (NSW) were followed-up to the end of 2004. Ri...

journal_title：BMC cancer

authors： Yu XQ,Chen WH,O'Connell DL

更新日期：2010-05-24 00:00:00

abstract：BACKGROUND:With the availability of effective anti-EGFR therapies for various solid malignancies, such as non-cell small lung cancer, colorectal cancer and squamous cell carcinoma of the head and neck, the knowledge of EGFR and K-RAS status becomes clinically important. The aim of this study was to analyse EGFR express...

journal_title：BMC cancer

authors： Van Damme N,Deron P,Van Roy N,Demetter P,Bols A,Van Dorpe J,Baert F,Van Laethem JL,Speleman F,Pauwels P,Peeters M

更新日期：2010-05-11 00:00:00

abstract：BACKGROUND:Cell-surface glycoproteins play critical roles in cell-to-cell recognition, signal transduction and regulation, thus being crucial in cell proliferation and cancer etiogenesis and development. DPP IV and NEP are ubiquitous glycopeptidases closely linked to tumor pathogenesis and development, and they are use...

journal_title：BMC cancer

authors： Varona A,Blanco L,Perez I,Gil J,Irazusta J,López JI,Candenas ML,Pinto FM,Larrinaga G

更新日期：2010-05-11 00:00:00

abstract：BACKGROUND:Spontaneous regression/complete resistance (SR/CR) mice are a unique colony of mice that possess an inheritable, natural cancer resistance mediated primarily by innate cellular immunity. This resistance is effective against sarcoma 180 (S180) at exceptionally high doses and these mice remain healthy. METHOD...

journal_title：BMC cancer

authors： Riedlinger G,Adams J,Stehle JR Jr,Blanks MJ,Sanders AM,Hicks AM,Willingham MC,Cui Z

更新日期：2010-05-03 00:00:00

abstract：BACKGROUND:Suppressors of cytokine signaling (SOCS) are important negative feedback regulators of the JAK/STAT signaling pathway, and have been recently investigated for their role in the development of different cancers. In this study, we examined the expression of SOCS1-7 genes in normal and breast cancer tissue and ...

journal_title：BMC cancer

authors： Sasi W,Jiang WG,Sharma A,Mokbel K

更新日期：2010-04-30 00:00:00

abstract：BACKGROUND:Large number of patients with colorectal liver metastasis show recurrent disease after curative surgical resection. Identification of these high-risk patients may guide therapeutic strategies. The aim of this study was to evaluate whether the presence of disseminated tumor cells in bone marrow from patients ...

journal_title：BMC cancer

authors： Vogelaar FJ,Mesker WE,Rijken AM,van Pelt GW,van Leeuwen AM,Tanke HJ,Tollenaar RA,Liefers GJ

更新日期：2010-04-20 00:00:00

abstract：BACKGROUND:Sarcomas are rare malignant tumors. Accurate initial histological diagnosis is essential for adequate management. We prospectively assessed the medical management of all patients diagnosed with sarcoma in a European region over a one-year period to identify the quantity of first diagnosis compared to central...

journal_title：BMC cancer

authors： Lurkin A,Ducimetière F,Vince DR,Decouvelaere AV,Cellier D,Gilly FN,Salameire D,Biron P,de Laroche G,Blay JY,Ray-Coquard I

更新日期：2010-04-19 00:00:00